Chromium or Chromate Dermatitis

Chromium content of lungs of chromate workers with lung cancer.

The chromium content was measured in the lungs of chromate workers, obtained at necropsy in six patients and at surgery in two. The mean chromium content of peripheral lung tissue was 36.7 micrograms per gm wet weight (range 0.50 to 130.2 micrograms) and that of the large airways was 0.51 micrograms per gm wet weight (range 0.22 to 0.99 micrograms). These means values were high compared with th...

Allergic chromium dermatitis from wearing 'chromium-free' footwear.

Mitochondrial reduction of the carcinogen chromate: formation of chromium(V).

Incubation of chromate with isolated rat liver mitochondria in vitro resulted in the uptake and reduction of chromium(VI), as well as the formation of chromium(V) species. Chromate was rapidly taken up and reduced by intact mitochondria. The rate of reduction of chromate by intact mitochondria was increased upon addition of succinate or malate plus glutamate, substrates for the electron-transpo...

Atopic dermatitis: allergic dermatitis or neuroimmune dermatitis?*

Advances in knowledge of neurocellulars relations have provided new directions in the understanding and treatment of numerous conditions, including atopic dermatitis. It is known that emotional, physical, chemical or biological stimuli can generate more accentuated responses in atopic patients than in non-atopic individuals; however, the complex network of control covered by these influences, e...

Chromium: friend or foe?

Chromium is an essential nutrient with many natural sources, but several investigators have presented evidence that healthy persons often have an inadequate intake of this metal. Advocates of its use as a dietary supplement believe that people with diabetes, lipoprotein abnormalities, and increased risk of cardiovascular disease may benefit from such supplementation. Others suggest a therapeuti...